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Selective Regulation of B-Raf Dependent K-Ras/Mitogen-Activated Protein by Natural Occurring Multi-kinase Inhibitors in Cancer Cells

Introduction: Cancer is one of the most difficult challenges faced by humanity due to its many associated issues, such as inability to prevent diseases, treatment safety, and high mortality rate. In cancer, a variety of cellular signaling is activated to ensure malignancy transformation, angiogenesis and metastasis. The most efficient signaling pathway in cancer is mitogen-activated protein kinase (MAPK), which controls malignancy and regulates apoptosis. Methods: Four different flavonoid glycosides have been isolated from Pulicaria jaubertii using the phytochemical characterization of hydro
Healthcare

Improved Semantic Segmentation of Low-Resolution 3D Point Clouds Using Supervised Domain Adaptation

One of the key challenges in applying deep learning to solve real-life problems is the lack of large annotated datasets. Furthermore, for a deep learning model to perform well on the test set, all samples in the training and test sets should be independent and identically distributed (i.i.d.), which means that test samples should be similar to the samples that were used to train the model. In many cases, however, the underlying training and test set distributions are different. In such cases, it is common to adapt the test samples by transforming them to their equivalent counterparts in the

Artificial Intelligence
Healthcare
Energy and Water
Software and Communications
Agriculture and Crops
Innovation, Entrepreneurship and Competitiveness

In-silico development and assessment of a Kalman filter motor decoder for prosthetic hand control

Up to 50% of amputees abandon their prostheses, partly due to rapid degradation of the control systems, which require frequent recalibration. The goal of this study was to develop a Kalman filter-based approach to decoding motoneuron activity to identify movement kinematics and thereby provide stable, long-term, accurate, real-time decoding. The Kalman filter-based decoder was examined via biologically varied datasets generated from a high-fidelity computational model of the spinal motoneuron pool. The estimated movement kinematics controlled a simulated MuJoCo prosthetic hand. This clear-box
Healthcare
Circuit Theory and Applications
Software and Communications
Mechanical Design
Innovation, Entrepreneurship and Competitiveness

Improved strain measuring using fast strain-encoded cardiac MR

The strain encoding (SENC) technique encodes regional strain of the heart into the acquired MR images and produces two images with two different tunings so that longitudinal strain, on the short-axis view, or circumferential strain on the long-axis view, are measured. Interleaving acquisition is used to shorten the acquisition time of the two tuned images by 50%, but it suffers from errors in the strain calculations due to inter-tunings motion of the heart, which is the motion between two successive acquisitions. In this work, a method is proposed to correct for the inter-tunings motion by

Healthcare
Circuit Theory and Applications
Innovation, Entrepreneurship and Competitiveness

Improved technique to detect the infarction in delayed enhancement image using k-mean method

Cardiac magnetic resonance (CMR) imaging is an important technique for cardiac diagnosis. Measuring the scar in myocardium is important to cardiologists to assess the viability of the heart. Delayed enhancement (DE) images are acquired after about 10 minutes following injecting the patient with contrast agent so the infracted region appears brighter than its surroundings. A common method to segment the infarction from DE images is based on intensity Thresholding. This technique performed poorly for detecting small infarcts in noisy images. In this work we aim to identify the best threshold

Healthcare
Circuit Theory and Applications
Innovation, Entrepreneurship and Competitiveness

Inherent fat cancellation in complementary spatial modulation of magnetization

An efficient fat suppression method is presented for MR tagging with complementary spatial modulation of magnetization (CSPAMM). In this method, the complementary modulation is applied to the water content of the tissues, while in-phase modulation is applied to the fat content. Therefore, during image reconstruction, the subtraction of the acquired images increases the tagging contrast of the water while cancels the tagging lines of the fat. Compared with the existing fat suppression techniques, the proposed method allows imaging with higher temporal resolution and shorter echo-time without
Healthcare
Circuit Theory and Applications
Innovation, Entrepreneurship and Competitiveness

In-Silico Comparative Analysis of Egyptian SARS CoV-2 with Other Populations: A Phylogeny and Mutation Analysis

In the current SARS-CoV2 pandemic, identification and differentiation between SARS-COV2 strains are vital to attain efficient therapeutic targeting, drug discovery and vaccination. In this study, we investigate how the viral genetic code mutated locally and what variations is the Egyptian population most susceptible to in comparison with different strains isolated from Asia, Europe and other countries in Africa. Our aim is to evaluate the significance of these variations and whether they constitute a change on the protein level and identify if any of these variations occurred in the conserved

Healthcare
Circuit Theory and Applications
Innovation, Entrepreneurship and Competitiveness

Improved estimation of the cardiac global function using combined long and short axis MRI images of the heart

Background: Estimating the left ventricular (LV) volumes at the different cardiac phases is necessary for evaluating the cardiac global function. In cardiac magnetic resonance imaging, accurate estimation of the LV volumes requires the processing a relatively large number of parallel short-axis cross-sectional images of the LV (typically from 9 to 12). Nevertheless, it is inevitable sometimes to estimate the volume from a small number of cross-sectional images, which can lead to a significant reduction of the volume estimation accuracy. This usually encountered when a number of cross-sectional
Artificial Intelligence
Healthcare
Circuit Theory and Applications
Innovation, Entrepreneurship and Competitiveness

In silico design and experimental validation of sirnas targeting conserved regions of multiple hepatitis c virus genotypes

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs (siRNAs) targeting highly conserved regions of the hepatitis C virus (HCV) genome. To aim for therapeutic applications by optimizing the RNAi efficacy and reducing potential side effects, we considered different factors such as target RNA variations, thermodynamics and accessibility of the siRNA
Healthcare
Innovation, Entrepreneurship and Competitiveness

Myocardium segmentation in strain-encoded (SENC) magnetic resonance images using graph-cuts

Evaluation of cardiac functions using Strain Encoded (SENC) magnetic resonance (MR) imaging is a powerful tool for imaging the deformation of left and right ventricles. However, automated analysis of SENC images is hindered due to the low signal-to-noise ratio SENC images. In this work, the authors propose a method to segment the left and right ventricles myocardium simultaneously in SENC-MR short-axis images. In addition, myocardium seed points are automatically selected using skeletonisation algorithm and used as hard constraints for the graph-cut optimization algorithm. The method is based
Healthcare
Software and Communications
Innovation, Entrepreneurship and Competitiveness