Up to 50% of amputees abandon their prostheses, partly due to rapid degradation of the control systems, which require frequent recalibration. The goal of this study was to develop a Kalman filter-based approach to decoding motoneuron activity to identify movement kinematics and thereby provide stable, long-term, accurate, real-time decoding. The Kalman filter-based decoder was examined via biologically varied datasets generated from a high-fidelity computational model of the spinal motoneuron pool. The estimated movement kinematics controlled a simulated MuJoCo prosthetic hand. This clear-box

One of the key challenges in applying deep learning to solve real-life problems is the lack of large annotated datasets. Furthermore, for a deep learning model to perform well on the test set, all samples in the training and test sets should be independent and identically distributed (i.i.d.), which means that test samples should be similar to the samples that were used to train the model. In many cases, however, the underlying training and test set distributions are different. In such cases, it is common to adapt the test samples by transforming them to their equivalent counterparts in the

Introduction: Cancer is one of the most difficult challenges faced by humanity due to its many associated issues, such as inability to prevent diseases, treatment safety, and high mortality rate. In cancer, a variety of cellular signaling is activated to ensure malignancy transformation, angiogenesis and metastasis. The most efficient signaling pathway in cancer is mitogen-activated protein kinase (MAPK), which controls malignancy and regulates apoptosis. Methods: Four different flavonoid glycosides have been isolated from Pulicaria jaubertii using the phytochemical characterization of hydro